XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, is a prescription medication used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. XEOMIN® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.
How does XEOMIN® work?
When you squint or frown, the muscles between your brows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.
Botulinum toxin type A — the active ingredient in XEOMIN® — acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the lines on your forehead between your brows.
Is XEOMIN proven?
XEOMIN was proven effective in two randomized, double-blind, multicenter, placebo controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Patients received 10 units of XEOMIN® and were classified as responders of they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Treatment success was higher with XEOMIN than placebo on Day 30 in both studies. Based on these trials, XEOMIN® received FDA approval for aesthetic use in 2011.
Is XEOMIN right for me?
If you are an adult with moderate to severe glabellar lines, XEOMIN may be right for you. Talk to you doctor to discuss the benefits and risks of treatment.
What can I expect during treatment?
During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN (incobotulinumtoxinA) for injection into the muscles in your forehead that cause frown lines between your brows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.
When can I expect to see results?
In clinical trials, some patients observed visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.
|Treatment Problem or Condition||Fine Lines, Wrinkles|
Typical duration of effect is up to 3 months but may last significantly longer or shorter in individual patients.
Your healthcare provider will recommend a treatment strategy to ensure that you receive the best possible results with XEOMIN® treatment. XEOMIN should be administered no more frequently than every three months.
Tell your doctor if you have any of these problems after treatment with XEOMIN:
- Problems with swallowing, speaking or breathing
- Spread of toxin effects, including muscle weakness all over the body, double vision, blurred vision, hoarseness, loss of voice, or loss of bladder control.
Do not take XEOMIN if you: are allergic to XEOMIN or any of the ingredients in XEOMIN; had an allergic reaction to any other botulinum toxin product; have a skin infection at the planned injection site.
Active ingredient: incobotulinumtoxinA
Inactive ingredients: human albumin and sucrose